You are not alone
Primary immunodeficiency (PI) doesn’t have to feel isolating.
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Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can manage it. Learn about PI diagnoses and treatment options.
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Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
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Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
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Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
We're here for you
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Get involved
Give
Our resources, services, and outreach are largely funded by donors like you.
Fundraise
Whether you join the IDF Sustainers Club or start a Facebook fundraiser, all efforts can make a difference.
Advocate
Even if you’re new to PI advocacy, there are many ways to raise awareness. We’ll help you get started.
Volunteer
Your gift of time makes a difference. There are always open positions for peer support and plasma awareness volunteers.
Transforming the lives of tens of thousands each year*
1.8 million
website sessions linking the community to vital resources.
1,774
individuals turned to AskIDF, allowing us to answer 2,226 PI-related questions.
34,034
individuals living with PI were supported and empowered.
*statistics based on 2025 Community Impact Report
Walk and Community Days
Step up for the immunocompromised community.
The 2026 Walk & Community Days season is here. Join us at one of our six in-person walk cities or our virtual, coast-to-coast walk, and help raise funds and awareness for immunocompromised individuals and their families.
Watch the full documentary on YouTube
"Compromised: Life Without Immunity" takes you inside the rarely-seen world of primary immunodeficiency. Through six powerful stories, discover how strength, support, and medical care make life possible despite seemingly impossible challenges. Watch for free on YouTube, or host a screening.
How well do you know your immune system?
Take our self-assessment to find out if your symptoms could point to a primary immunodeficiency (PI). It’s an informative way to gather insights that you can discuss with your healthcare provider.
A combined impact: More than just fun and games
When two of the internet's most engaging content creators—CDawgVA (Connor Colquhoun) and VTuber Ironmouse—came together to support the Immune Deficiency Foundation, something extraordinary happened. What began as a friendship between a charismatic streamer and a talented VTuber living with common variable immune deficiency (CVID) has grown into one of the most impactful partnerships in content creator fundraising.
Let us guide you.
If you are living with PI, think you might have PI, are a caregiver, a healthcare professional, or are just looking to learn more we can help.
Who is the Immune Deficiency Foundation?
Learn and share
Be a Plasma Hero
The more we learn about plasma, the more we realize its life-saving potential. We need heroes to step up, donate, and save lives.
Promote plasma donation
Types of PI
There are more than 550 primary immunodeficiencies, also known as inborn errors of immunity (IEI).
Explore PI types
Recursos en español
¡Bienvenidos! Para ver nuestros recursos disponibles, haga clic en el siguiente enlace.
Ver los recursos
IDF podcast
Listen to the latest episode of the IDF Podcast, or one of our sub-series Undiagnosed or Bold Conversations.
Listen or subscribe
Videos & recordings
Join IDF on YouTube to help spread awareness and education about PI and tune in to see what is happening.
Watch videos
Immunocompromised Collaborative
Joining forces to protect the most vulnerable against infectious disease.
Learn about the collaborative
Join an event
Learn more about all the ways to learn, connect, and engage with the Immune Deficiency Foundation, whether online and in person.
Stay informed
Browse the latest news articles, videos, and podcasts to find the most up-to-date information about advancements in PI treatments, portrayal in the media, and other IDF efforts.
Sign up for updates
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